What is the starting dose of sermorelin?

Common adult research-context starting guidance is 100-200 mcg subQ at bedtime for the first 1-2 weeks, then titrating to 200-300 mcg nightly.

How much BAC water do you use to reconstitute a 10 mg sermorelin vial?

A common research-context setup is 3 mL of bacteriostatic water in a 10 mg vial.

How many units of sermorelin should I inject?

It depends on your vial size and how much BAC water you used.

What is sermorelin's half-life?

Sermorelin's plasma half-life is approximately 11-12 minutes after either IV or subQ injection.

Is sermorelin FDA-approved in 2026?

Sermorelin was FDA-approved in 1990 and 1997, but there is no currently marketed FDA-approved product as of June 2026.

Is sermorelin legal to compound in 2026?

Yes, sermorelin remains in FDA 503A Category 1, allowing licensed compounding pharmacies to prepare it.

What are the most common side effects of sermorelin?

The most common side effect was a mild injection-site reaction in about 1 in 6 participants.

What results can be expected from sermorelin?

Sleep and recovery changes often appear in 2-4 weeks, while body-composition shifts usually need 3-6 months.

Hormone-related

Sermorelin Acetate

Sermorelin is a synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH) studied in growth-hormone axis research.

Researched for

LongevitySleepBody CompositionMetabolic HealthRecovery

Not yet audited

We have not published an audit on Sermorelin Acetate. Everything below is reference material, not our own reading of the literature, treat it as a starting point for questions, not as a grade.

How it is thought to work

Sermorelin is a small peptide that copies the first 29 amino acids of the body's natural growth hormone-releasing hormone (GHRH). It fits the pituitary gland's GHRH receptor, triggering a normal growth hormone (GH) pulse. [Source: Peptide Dosing Protocols]

Sermorelin is a short copy of the brain signal that tells the pituitary gland to release growth hormone, and because it works through the body's own system, the body's natural safety brake (somatostatin) stays active to prevent growth hormone from going too high.

Reported side effects

The most common side effect is mild pain, swelling, or redness at the injection site (seen in about 17% of trial participants), while less common effects like headache, flushing, dizziness, and nausea each occurred in under 1% of patients.

Who should avoid it

People who are pregnant or breastfeeding, have active cancer, a known allergy to sermorelin, untreated hypothyroidism, are on glucocorticoids, or have GH deficiency caused by a brain lesion should generally avoid sermorelin, and anyone using it should do so under the supervision of a licensed clinician.

Amount	Frequency	Route	Reported by
Standard: 200-300 mcg · Low: 100 mcg · High: 400-500 mcg	nightly3-6 months · Cycle length Planning note 4 weeks 1 vial 28 nights of 200 mcg from one vial.	subcutaneous injection	Peptide Dosing Protocols What it saysHide (secondary reference; provider confirmation required). Half-life: 11-12 minutes. Common dose is 200-300 mcg subQ nightly.
200-300 mcg	Once daily at bedtime, 5 nights per week3-6 months	subcutaneous or oral	Peptide Protocol Wiki What it saysHide (secondary reference; provider confirmation required).