Advanced Recomp Stack
Combination stack studied for body recomposition (fat loss and lean-mass support).
This is a combination sold as one vial. It has not been studied as a single substance, so what is known is what is known about each part. Sources that report a dose for the blend report it for that mixture, not for any component on its own.
We have not published an audit on Advanced Recomp Stack. Everything below is reference material, not our own reading of the literature, treat it as a starting point for questions, not as a grade.
How it is thought to work
Multi-compound stack targeting body composition; components and mechanism per source.
Retatrutide drives fat loss by activating three metabolic receptors at once, while CJC-1295 and ipamorelin work through separate growth-hormone receptors to amplify GH pulses and help preserve muscle during the aggressive caloric deficit.
Reported side effects
The main safety concerns are GI side effects from retatrutide escalation, potential glucose and cardiovascular changes, and the critical risk of a 1,000x dosing error from confusing the mg (retatrutide) and mcg (CJC/Ipa) units.
Who should avoid it
People with diabetes, thyroid cancer history, MEN2 history, gallbladder or pancreatitis history, sleep apnea, edema, kidney disease, or cancer history should discuss baseline labs with a clinician before starting, and competitive athletes subject to WADA testing should be aware CJC-1295 and ipamorelin are prohibited.
What gets monitored
IGF-1 (follow-up); HbA1c (baseline); Fasting glucose (follow-up); Comprehensive metabolic panel / CMP, kidney function, liver enzymes, electrolytes, glucose (baseline); Lipid panel (follow-up); Blood pressure and resting heart rate (follow-up). Re-check metabolic markers and IGF-1 after 6-8 weeks. For longer protocols, review metabolic, IGF-1, kidney, liver, and cardiovascular trends every 3 months with a clinician. [Source: peptidedosingprotocols.com]
What sources report
These are figures published elsewhere, reproduced with their source. Peppersite does not recommend an amount for Advanced Recomp Stack or for anything else, and nothing below has been checked against the study it came from.
| Amount | Frequency | Route | Reported by |
|---|---|---|---|
| Retatrutide: 2 mg/week (initiation, weeks 1-4) escalating to 12 mg/week (maximum, weeks 17-20+); CJC-1295 (No DAC): 100-200 mcg, 1-2x daily; Ipamorelin: 100-200 mcg, 1-2x daily | Retatrutide: once weekly; CJC-1295 and ipamorelin: 1-2x daily (5-on / 2-off rhythm)Standard cycle 12-16 weeks; Extended cycle 16-24 weeks; Continuous retatrutide + cycled CJC/Ipa (12 weeks on / 4 weeks off). CJC/Ipa cycled 12 weeks on / 4 weeks off; retatrutide can continue. | subcutaneous | peptidedosingprotocols.comWhat it saysHide(secondary reference; provider confirmation required). [Source: peptidedosingprotocols.com] |
- Retatrutide: once weekly; CJC-1295 and ipamorelin: 1-2x daily (5-on / 2-off rhythm)Standard cycle 12-16 weeks; Extended cycle 16-24 weeks; Continuous retatrutide + cycled CJC/Ipa (12 weeks on / 4 weeks off). CJC/Ipa cycled 12 weeks on / 4 weeks off; retatrutide can continue.
- subcutaneous
- peptidedosingprotocols.com
What it saysHide
(secondary reference; provider confirmation required). [Source: peptidedosingprotocols.com]
- Retatrutide: 5 mg vial + 1 mL BAC water = 5 mg/mL; 10 mg vial + 2 mL BAC water = 5 mg/mL; 10 mg vial + 1 mL BAC water = 10 mg/mL; 20 mg vial + 2 mL BAC water = 10 mg/mL. Volumes over 1.0 mL need a larger syringe or a split injection at two sites. CJC-1295 (No DAC): 2 mg vial + 1 mL BAC water = 2,000 mcg/mL; 5 mg vial + 2 mL BAC water = 2,500 mcg/mL; 5 mg vial + 2.5 mL BAC water = 2,000 mcg/mL. Ipamorelin: same math as CJC-1295. Pre-blended CJC/Ipa combo vial (10 mg = 5 mg CJC + 5 mg ipamorelin): reconstitute with 2 mL BAC water for 2,500 mcg/mL per peptide; 8 units (0.08 mL) = ~200 mcg of each. Label every vial with compound name, concentration, and reconstitution date. Retatrutide is dosed in mg; CJC/Ipa in mcg, a 1,000x difference. Use U-100 insulin syringes.
Common questions
What is the Advanced Recomp Stack?
The Advanced Recomp Stack combines retatrutide, CJC-1295 (No DAC), and ipamorelin in a 3-compound body recomposition protocol. Retatrutide drives fat loss. CJC-1295 + ipamorelin boost growth hormone to support lean tissue during the deficit. No published human trial has tested all three together.
Can you stack retatrutide with CJC-1295 and ipamorelin together?
Yes. Retatrutide and CJC-1295 + ipamorelin work through completely different receptor systems. Retatrutide hits metabolic receptors (GLP-1, GIP, glucagon). CJC and ipamorelin hit growth-hormone receptors (GHRH-R, GHS-R1a). There is no receptor overlap. The combination is community-derived, not from a clinical trial.
How is the Advanced Recomp Stack dosed?
Retatrutide is dosed once a week via subQ injection, titrated from 2 mg up to 9-12 mg over 16-20 weeks. CJC-1295 (No DAC) and ipamorelin are each dosed at 100-200 mcg per shot, 1-2 times daily, with the main shot before bed in a fasted state.
Should I use a pre-blended CJC + ipamorelin vial or separate vials?
Most users pick the pre-blended CJC/Ipa combo vial because it cuts reconstitution from three vials to two and locks in a 1:1 ratio. Separate vials are better if you need to run one peptide higher than the other. Retatrutide always stays as its own separate vial.
How do you reconstitute the Advanced Recomp Stack?
Each compound is reconstituted on its own. Common setups: retatrutide 10 mg + 2 mL BAC water = 5 mg/mL; CJC-1295 2 mg + 1 mL BAC water = 2,000 mcg/mL; ipamorelin 5 mg + 2.5 mL BAC water = 2,000 mcg/mL. For a pre-blended CJC + ipa combo vial (5 mg + 5 mg) reconstituted with 2 mL BAC water, you get 2,500 mcg/mL of each peptide.
Open the reconstitution calculator →Why use CJC-1295 without DAC instead of the with-DAC version?
CJC-1295 No DAC produces short GH pulses — your levels spike, then come back down, which matches the body's natural rhythm. The with-DAC version keeps GH elevated for days. This stack is built around natural-style pulses, so the No DAC version is the intended fit. No DAC is also easier to adjust if you need to change your dose.
How long should you run the Advanced Recomp Stack?
Standard cycles run 12-16 weeks. Extended cycles run 16-24 weeks. CJC-1295 + ipamorelin are usually cycled 12 weeks on and 4 weeks off to reduce receptor desensitization. Retatrutide can continue through the CJC/Ipa off-period when ongoing weight-management support is needed.
Is the Advanced Recomp Stack safe? What are the main risks?
No clinical trial has tested all three together. The biggest known risks are retatrutide-driven GI side effects (nausea 38-43%, diarrhea 33-35%) and dysesthesia — an unusual skin tingling or burning sensation at higher doses. Adding CJC/Ipa brings injection-site reactions and mild water retention. People with pre-diabetes or insulin resistance should monitor blood glucose more often because retatrutide and GH push insulin sensitivity in opposite directions.
Sources
The reference sections above are imported from our compound knowledge base, which classes the evidence for Advanced Recomp Stack as emerging. That classification is the knowledge base’s, not ours, our own grade appears only where an audit is linked above. Research use only; nothing here is medical advice or a protocol.
Sermorelin is a synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH) studied in growth-hormone axis research.
Blend of Tesamorelin (GHRH analog) and Ipamorelin (GHRP), studied for GH-axis support, visceral fat, and recovery.
Glutathione is a tripeptide antioxidant central to cellular redox biology research.
Blend of retatrutide (triple incretin agonist) and MOTS-c (mitochondrial-derived peptide), studied for metabolic and body-composition research.
Semaglutide is one of the most widely studied weight-loss and diabetes drugs in the world.
5-Amino-1MQ is a small molecule studied for its potential to help the body shrink fat cells and raise NAD+ levels without cutting appetite.