Pinealon
Pinealon is a synthetic three-amino-acid peptide primarily studied for its potential effects on brain aging and memory.
We have not published an audit on Pinealon. Everything below is reference material, not our own reading of the literature, treat it as a starting point for questions, not as a grade.
How it is thought to work
Pinealon is believed to help brain cells manage oxidative stress and support cognitive functions, although these effects are still experimental and not proven in large human trials. [Source: Peptide Dosing Protocols]
Pinealon is a tiny three-amino-acid peptide (Glu-Asp-Arg) that is thought to be small enough to enter the cell nucleus and directly influence which genes are turned on or off, particularly genes involved in protecting brain cells from oxidative stress and supporting neuron survival.
Reported side effects
The most commonly reported side effects are mild early-cycle headache, sleep changes such as vivid dreams in the first week, mild stomach upset with oral use, and injection-site redness or itching with subcutaneous use.
Who should avoid it
Pregnant or breastfeeding individuals, people with a cancer history, seizure disorders, children, anyone on CNS medications, and those with known peptide allergies should avoid Pinealon.
What sources report
These are figures published elsewhere, reproduced with their source. Peppersite does not recommend an amount for Pinealon or for anything else, and nothing below has been checked against the study it came from.
| Amount | Frequency | Route | Reported by |
|---|---|---|---|
| Standard: 1.0 to 2.0 mg per day · Low: 1.0 mg · High: 2.0 mg | Once daily10 to 20 days · 2 to 3 cycles per year | subcutaneous injection or oral | Peptide Dosing ProtocolsWhat it saysHide(secondary reference; provider confirmation required). Pinealon is typically dosed at 1.0 to 2.0 mg per day. |
- Once daily10 to 20 days · 2 to 3 cycles per year
- subcutaneous injection or oral
- Peptide Dosing Protocols
What it saysHide
(secondary reference; provider confirmation required). Pinealon is typically dosed at 1.0 to 2.0 mg per day.
- 3.0 mL BAC water
Common questions
What is Pinealon?
Pinealon is a synthetic three-amino-acid peptide with the sequence Glu-Asp-Arg, also called the EDR peptide.
Is Pinealon FDA-approved?
No, as of June 2026, Pinealon has no FDA-approved indication.
How is Pinealon dosed in research planning?
Published reports used 20 mg per day orally for 10–20 days.
Can Pinealon be taken orally?
Yes, oral capsules at around 20 mg per day are commonly used.
How is Pinealon reconstituted?
Add 3.0 mL of bacteriostatic water to a 20 mg vial.
Check 20 mg in 3 mL in the calculator →How long is a typical Pinealon cycle?
Cycles run 10 to 20 days, sometimes extended to 28 days.
What supplies are needed for a Pinealon cycle?
1–2 vials, one fresh U-100 insulin syringe per day, and a 10 mL bottle of bacteriostatic water.
What are the main Pinealon side effects?
Reported effects include mild headache, sleep changes, gastrointestinal effects, and injection-site redness.
Sources
- 01Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Research (2011)
- 02Kraskovskaya NA, Kukanova EO, Lin'kova NS, Popugaeva EA, Khavinson VKh. Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease. Bulletin of Experimental Biology and Medicine (2017)
- 03Khavinson VKh, Lin'kova NS, Kvetnoy IM, et al. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules (MDPI) (2021)
- 04Arutjunyan A, Kozina L, Stvolinskiy S, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. International Journal of Clinical and Experimental Medicine (2012)
- 05Karantysh GV, Mendzheritskii AM, Ryzhak GA, et al. Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes. Neurochemical Journal (2020)
- 06Khavinson VKh, Tarnovskaya SI, Lin'kova NS, et al. Short Peptides and Telomere Length Regulator Hormone Irisin. Bulletin of Experimental Biology and Medicine (2016)
- 07Khavinson VKh, Lin'kova NS, Umnov RS. Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease. Bulletin of Experimental Biology and Medicine (2021)
- 08Meshchaninov VN, Tkachenko EL, Zharkov SV, et al. Effect of synthetic peptides on aging of patients with chronic polymorbidity and organic brain syndrome of the central nervous system in remission. Advances in Gerontology (2015)
- 09National Center for Biotechnology Information. PubChem Compound Summary for CID 10273502, Pinealon (Glu-Asp-Arg). PubChem (2026)
- 10U.S. Food and Drug Administration. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (Category 1 list). FDA.gov (2026)
The reference sections above are imported from our compound knowledge base, which classes the evidence for Pinealon as emerging. That classification is the knowledge base’s, not ours, our own grade appears only where an audit is linked above. Research use only; nothing here is medical advice or a protocol.
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