What is epitalon and what is it used for?

Epitalon is a synthetic four-amino-acid peptide studied for aging, mainly for its effect on telomeres and the sleep-melatonin cycle.

What does epitalon do?

In lab studies, epitalon raised telomerase activity and allowed cells to divide more times than usual.

How is epitalon commonly dosed in research?

Common dosing is about 5 mg per day by subcutaneous injection for 20 days, or 10 mg per day for 10 days, repeated two to three times a year.

How do you reconstitute epitalon?

For a 10 mg vial, add 2.0 mL of bacteriostatic water to achieve a concentration of 5 mg/mL.

When should epitalon be taken, and where is it injected?

Most protocols use evening dosing and the common route is subcutaneous injection into the fat under the skin.

What is the half-life of epitalon?

Epitalon clears the bloodstream very quickly, on the order of minutes.

What are the side effects of epitalon?

Reported side effects are usually mild and injection-related, such as redness or soreness at the site.

Is epitalon FDA-approved?

No, as of June 2026, epitalon is not FDA-approved for any use.

Peptidesubcutaneous

Epitalon

Epithalon (epitalon) is a synthetic tetrapeptide studied in telomere and pineal-axis research models.

Researched for

LongevitySleepCognitive Support

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Not yet audited

We have not published an audit on Epitalon. Everything below is reference material, not our own reading of the literature, treat it as a starting point for questions, not as a grade.

How it is thought to work

Telomerase/circadian-related signaling (largely preclinical).

Epitalon is a four-amino-acid peptide studied for its potential effects on telomeres (the protective caps on DNA) and the body's sleep/melatonin clock, with lab and animal research suggesting it may raise telomerase activity and support circadian rhythms, though no large blinded human trial has confirmed these effects.

Reported side effects

The most commonly reported side effects are mild injection-site reactions (redness, soreness, or a small bump), mild drowsiness with evening dosing, and occasional headache or temporary sleep changes at the start of a cycle, though the larger concern is unknown long-term safety and a theoretical risk related to telomerase activation in people with cancer history.

What sources report

Reference, not a recommendation

These are figures published elsewhere, reproduced with their source. Peppersite does not recommend an amount for Epitalon or for anything else, and nothing below has been checked against the study it came from.

Amount	Frequency	Route	Reported by
5-10 mg per day	Once daily	subcutaneous or oral	Peptide Protocol Wiki What it saysHide (secondary reference; provider confirmation required).
Standard: 5 mg/day · High: 10 mg/day	2-3 times per year20 days · short cycle	SubQ	Peptide Dosing Protocols What it saysHide (secondary reference; provider confirmation required). Half-life: half-life of epitalon? Epitalon clears the bloodstream very quickly, on the order of minutes, whic. The standard dosing for Epitalon is 5 mg per day for 20 days.
Referenced at 10 mg daily for 10 days followed by a break; longevity stacking contexts cite 2-3 cycles per year. General dosage guideline of 5-10 mg per cycle also referenced.	Daily during 10-day cycle · Evening cited for sleep-phase cellular repair; morning for circadian alignment10-day cycles, 2-3 per year	subcutaneous or nasal	Peptide Therapy Reference Text, internal KB v4 What it saysHide (Aug 2026), secondary reference; provider confirmation required.

5-10 mg per day

Frequency: Once daily
Route: subcutaneous or oral
Reported by: Peptide Protocol Wiki
What it saysHide
(secondary reference; provider confirmation required).

Standard: 5 mg/day · High: 10 mg/day

Frequency: 2-3 times per year20 days · short cycle
Route: SubQ
Reported by: Peptide Dosing Protocols
What it saysHide
(secondary reference; provider confirmation required). Half-life: half-life of epitalon? Epitalon clears the bloodstream very quickly, on the order of minutes, whic. The standard dosing for Epitalon is 5 mg per day for 20 days.

Referenced at 10 mg daily for 10 days followed by a break; longevity stacking contexts cite 2-3 cycles per year. General dosage guideline of 5-10 mg per cycle also referenced.

Reconstitution, as reported

Bacteriostatic water
Add 2.0 mL BAC water to a 10 mg vial.