Selank
Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, studied in anxiolytic and neurotrophic research models.
We have not published an audit on Selank. Everything below is reference material, not our own reading of the literature, treat it as a starting point for questions, not as a grade.
How it is thought to work
Modulation of neuropeptide and immune signaling.
Selank is a peptide that calms anxiety by acting on GABA receptors, serotonin, dopamine, and the brain's natural calming molecules (enkephalins), while also supporting brain growth signals, all without the sedation or dependence seen with typical anti-anxiety drugs.
Reported side effects
The most commonly reported side effects of Selank are mild injection-site redness (with SubQ use), nasal stinging or dryness (with intranasal use), and a mild headache in the first few days, all of which are generally short-lived.
Who should avoid it
Selank should be avoided by anyone who is pregnant, breastfeeding, or trying to conceive, has an unmanaged psychiatric condition, has had allergic reactions to peptide products, is taking prescription anxiolytics or antidepressants without clinician oversight, or has an immune system disorder.
What sources report
These are figures published elsewhere, reproduced with their source. Peppersite does not recommend an amount for Selank or for anything else, and nothing below has been checked against the study it came from.
| Amount | Frequency | Route | Reported by |
|---|---|---|---|
| 250-500 mcg intranasally daily (or 0.15% solution per protocol) | once or twice daily10-14 day cycles · Repeat cycles per provider direction | intranasal | Commonly published practitioner dosing range - provider confirmation required. |
| 300-600 mcg per dose intranasal; 200-400 mcg per dose subcutaneous | 2-3 times daily (intranasal); once daily (SC, 5 days per week)30 days on, 30 days off; approximately 6 | subcutaneous or intranasal or oral | Peptide Protocol WikiWhat it saysHide(secondary reference; provider confirmation required). |
| Standard: 250-500 mcg per day · Low: 250 mcg · High: 500 mcg | once daily for SubQ; 14-21 days for intranasal4 weeks for SubQ; 14-21 days for intranasal · 4 weeks on, 4 weeks off for SubQ; 1-3 weeks off for intranasal | Subcutaneous injection (SubQ) or intranasal nasal spray | Peptide Dosing Protocols |
Common questions
What is Selank?
Selank is a Russian-developed peptide studied for anxiety relief and mild focus support.
What is the typical Selank dosage?
Subcutaneous research-use protocols use 250-500 mcg per day, usually starting at 250-300 mcg.
What is Selank's half-life?
The plasma half-life is short — about 2-10 minutes.
How is Selank reconstituted?
Add bacteriostatic water to the 30 mg lyophilized vial using sterile technique.
Open the reconstitution calculator →Is Selank a nasal spray?
In Russia, Selank is sold as a prescription nasal spray for anxiety disorders.
Is Selank FDA-approved?
No, Selank is not FDA-approved as of June 2026.
What are the most common Selank side effects?
The most common side effects are mild injection-site irritation, mild nasal stinging or dryness, and occasional mild headache.
How does Selank compare to Semax?
Selank is anxiety-first, while Semax is focus-first.
Sources
- 01Zozulia AA, Neznamov GG, Siuniakov TS, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova (2008)
- 02Seredenin SB, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova (2014)
- 03Seredenin SB, et al. Optimization of the treatment of anxiety disorders with selank. Zh Nevrol Psikhiatr Im S S Korsakova (2015)
- 04Uchakina ON, Uchakin PN, Miasoedov NF, et al. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Bulletin of Experimental Biology and Medicine (2008)
- 05Volkova A, Bondarenko E, Wei H, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology (2016)
- 06
The reference sections above are imported from our compound knowledge base, which classes the evidence for Selank as emerging. That classification is the knowledge base’s, not ours, our own grade appears only where an audit is linked above. Research use only; nothing here is medical advice or a protocol.
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Epithalon (epitalon) is a synthetic tetrapeptide studied in telomere and pineal-axis research models.
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Semax is a synthetic heptapeptide analog of ACTH(4-10) studied in nootropic and neurotrophic research models.